Are European marketed acyclovir 5% cream products similar? Comparison with EU and US reference product

The aim was to perform a comparative evaluation of composition and in vitro release performance of multisource acyclovir 5% creams.The outcome was analyzed in relation with the principles of the Topical drug Classification System (TCS).The in vitro drug release testing (IVRT) was based on selection of an inert artificial membrane and a medium providing sink conditions, and utilizing the vertical diffusion cells. US and European innovator...