Growth Suppression of Cancer Spheroids With Mutated KRAS by Low-toxicity Compounds from Natural Products
Abstract
Abstract
Background/Aim: Among compounds from natural products selectively suppressing the growth of cancer spheroids, which have mutant (mt) KRAS, NP910 was selected and its derivatives explored. Materials and Methods: The area of HKe3 spheroids expressing wild type (wt) KRAS (HKe3-wtKRAS) and mtKRAS (HKe3-mtKRAS) were measured in three-dimensional floating (3DF) cultures treated with 18 NP910 derivatives. The 50% cell growth...Paper Details
Title
Growth Suppression of Cancer Spheroids With Mutated KRAS by Low-toxicity Compounds from Natural Products
Published Date
Jul 19, 2021
Journal
Volume
41
Issue
8
Pages
4061 - 4070
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