river_71121

gene pairs

lavender

Trends in Genetics

Gene duplication events are major factors in shaping eukaryotic genomes. Systematic analysis of complex genetic interactions of duplicated genes revealed that their functional redundancy is evolutionary stable and can coevolve with acquisition of functional specialization due to structural and functional entanglement factors. Structural constraints that lead to maintenance of functionally overlapping duplicated genes include protein–protein interactions that maintain heteromers between sister duplicates.

Retention of duplicated genes in evolution