Identification of Cancer Cell Population Dynamics Leveraging the Effect of Pre-Treatment for Drug Schedule Design

Sequences of different drugs have shown potential to improve treatment strategies for cancer. Typical switched system approaches model the population dynamics of each drug independently, not rigorously considering the effects of pretreatment or drug-drug interactions. In this paper, a general model family incorporating pre-treatment effects and biological domain knowledge is proposed, and a model from this family is identified by using a novel...