Internal medicine

Hazard ratio

Amputation

Vascular disease

Arterial disease

Relative risk

Meta-analysis

Surgery

Subgroup analysis

Randomized controlled trial

Claudication

Lower risk

Intermittent claudication

Confidence interval

Medicine

European Journal of Vascular and Endovascular Surgery

There have been concerns about the long term safety of paclitaxel coated devices in the lower limbs. A formal systematic review and meta-analysis of randomised controlled trials (RCTs) was performed to examine the long term risk of major amputation using paclitaxel coated balloons in peripheral arterial disease (PAD).

Editor's Choice – Risk of Major Amputation Following Application of Paclitaxel Coated Balloons in the Lower Limb Arteries: A Systematic Review and Meta-Analysis of Randomised Controlled Trials