Theaflavin binds to a druggable pocket of TMEM16A channel and inhibits lung adenocarcinoma cell viability

Volume: 297, Issue: 3, Pages: 101016 - 101016
Published: Sep 1, 2021
Abstract
As a calcium-activated chloride channel regulated by the intracellular Ca2+ concentration and membrane potential, TMEM16A has attracted considerable attention and has been proposed as a novel anticancer drug target. We have previously reported that the pocket above the ion conductance pore could be a nonselective inhibitor-binding pocket. However, whether this pocket is druggable remains unexplored. In this study, we performed virtual screening...
Paper Details
Title
Theaflavin binds to a druggable pocket of TMEM16A channel and inhibits lung adenocarcinoma cell viability
Published Date
Sep 1, 2021
Volume
297
Issue
3
Pages
101016 - 101016
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