In-vivo Sonoporation Effect Under the Presence of a Large Amount of Micro-Nano Bubbles in Swine Liver

Sonoporation as a method of intracellular drug and gene delivery has not yet progressed to being used in vivo. This is likely because the cavitation effect is too small to reach a level practical for in vivo use. The aim of this study was to prove the feasibility of sonoporation at a level practical for use in vivo by injecting a large amount of carbon dioxide micro-nanobubbles into swine livers and applying ultrasound irradiation. Nine swine...