The two faces of cyanide: an environmental toxin and a potential novel mammalian gasotransmitter.
Abstract
Cyanide is traditionally viewed as a cytotoxic agent, with its primary mode of action being the inhibition of mitochondrial Complex IV (cytochrome c oxidase). However, recent studies demonstrate that the effect of cyanide on Complex IV in various mammalian cells is biphasic: in lower concentrations (nanomolar to low micromolar) cyanide stimulates Complex IV activity, increases ATP production and accelerates cell proliferation, while at higher...
Paper Details
Title
The two faces of cyanide: an environmental toxin and a potential novel mammalian gasotransmitter.
Published Date
Aug 5, 2021
Journal
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Notes
History