A novel humanized cutaneous lupus erythematosus mouse model mediated by IL-21-induced age-associated B cells
Abstract
Cutaneous lupus erythematosus (CLE) is a relapsing autoimmune disease, but key elements that drive disease initiation and progression remain elusive. To date, the lack of ideal murine model which resemble human cutaneous lupus makes it extremely challenging for moving mechanistic discoveries and novel therapeutics. Here, we prompt a humanized murine model to develop an inducible rapid-onset murine that performs cutaneous rather than systemic...
Paper Details
Title
A novel humanized cutaneous lupus erythematosus mouse model mediated by IL-21-induced age-associated B cells
Published Date
Sep 1, 2021
Journal
Volume
123
Pages
102686 - 102686
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