Multiomic analysis on human cell model of wolfram syndrome reveals changes in mitochondrial morphology and function

Volume: 19, Issue: 1
Published: Nov 20, 2021
Abstract
Wolfram syndrome (WFS) is a rare autosomal recessive syndrome in which diabetes mellitus and neurodegenerative disorders occur as a result of Wolframin deficiency and increased ER stress. In addition, WFS1 deficiency leads to calcium homeostasis disturbances and can change mitochondrial dynamics. The aim of this study was to evaluate protein levels and changes in gene transcription on human WFS cell model under experimental ER stress.We...
Paper Details
Title
Multiomic analysis on human cell model of wolfram syndrome reveals changes in mitochondrial morphology and function
Published Date
Nov 20, 2021
Volume
19
Issue
1
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