Docetaxel Skin Exposure and Micronucleation Contributes to Skin Toxicity Caused by CPC634
Abstract
Docetaxel entrapped nanoparticle CPC634 is associated with dose-related skin toxicity that resembles conventional docetaxel (Cd)-related skin toxicity. This study compared the cutaneous pharmacokinetics and pharmacodynamics of docetaxel and CPC634. In this randomised cross-over study, patients with solid tumours received one cycle of CPC634 and Cd (both at 75 mg/m2). Skin biopsies were taken at baseline and at day 8 of both cycles. Released and...
Paper Details
Title
Docetaxel Skin Exposure and Micronucleation Contributes to Skin Toxicity Caused by CPC634
Published Date
Jul 26, 2021
Journal
Volume
13
Issue
15
Pages
3741 - 3741
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