Auto-Antibody Production During Experimental Atherosclerosis in ApoE-/- Mice
Abstract
Current models stipulate that B cells and antibodies function during atherosclerosis in two distinct ways based on antibody isotype, where IgM is protective and IgG is inflammatory. To examine this model, we generated ApoE-/- Aid-/- mice, which are unable to produce IgG antibodies due to the absence of activation-induced deaminase (AID) but maintain high plasma cholesterol due to the absence of apolipoprotein E (APOE). We saw a dramatic decrease...
Paper Details
Title
Auto-Antibody Production During Experimental Atherosclerosis in ApoE-/- Mice
Published Date
Jul 9, 2021
Journal
Volume
12
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