Prognostic biomarkers in pancreatic neuroendocrine tumors

Although pancreatic neuroendocrine tumors (PanNETs) are rare neoplasms, this tumor type represents the second most common pancreatic malignancy and is gradually increasing in incidence. Representing a clinically challenging disease, PanNETs encompass a heterogeneous spectrum of tumors that vary in clinical presentation, natural history, and prognosis.1 For example, some patients present with a slow growing, indolent tumor, whereas other patients...