Thioredoxin reductase is a major regulator of metabolism in leukemia cells

Volume: 40, Issue: 33, Pages: 5236 - 5246
Published: Jul 8, 2021
Abstract
Despite the fact that AML is the most common acute leukemia in adults, patient outcomes are poor necessitating the development of novel therapies. We identified that inhibition of Thioredoxin Reductase (TrxR) is a promising strategy for AML and report a highly potent and specific inhibitor of TrxR, S-250. Both pharmacologic and genetic inhibition of TrxR impairs the growth of human AML in mouse models. We found that TrxR inhibition leads to a...
Paper Details
Title
Thioredoxin reductase is a major regulator of metabolism in leukemia cells
Published Date
Jul 8, 2021
Journal
Volume
40
Issue
33
Pages
5236 - 5246
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