Novel rapid-acting glutamatergic modulators: Targeting the synaptic plasticity in depression
Abstract
Major depressive disorder (MDD) is severely prevalent, and conventional monoaminergic antidepressants gradually exhibit low therapeutic efficiency, especially for patients with treatment-resistant depression. A neuroplasticity hypothesis is an emerging advancement in the mechanism of depression, mainly expressed in the glutamate system, e.g., glutamate receptors and signaling. Dysfunctional glutamatergic neurotransmission is currently considered...
Paper Details
Title
Novel rapid-acting glutamatergic modulators: Targeting the synaptic plasticity in depression
Published Date
Sep 1, 2021
Journal
Volume
171
Pages
105761 - 105761
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