Abstract 2167: Genomic profiling of pediatric and adolescent ependymomas: Underlying genetic alterations for prognosis and therapeutic orientation

Background: Ependymoma (EPN) is the third most common brain tumor in children and adolescents and is incurable in up to 40% cases, as chemotherapy is ineffective in most individuals and treatment remains challenging. A genetic panel based on next-generation sequencing (NGS) technology and developed exclusively for pediatric neoplasms is essential in order to determine prognosis and therapeutic managements in EPN, as this tumor comprise several...