Abstract 3127: A transcriptional lineage tracing approach to unravel crucial gene expression patterns in breast cancer progression

Breast cancer represents a major clinical hurdle, with intra-tumor heterogeneity and metastatic outcome accounting for poor prognosis. Traditionally, its poly-clonal structure was investigated through the genetic barcoding of cells followed by the tracing of the offspring. However, this analysis does not allow a solid investigation of the transcriptional profile associated to clones throughout tumor progression. In this work, we exploited a...