Abstract 393: Predictive biomarker evaluation and molecular differentiation for imipridones ONC201 and ONC206

Imipridone ONC201 is a first-in-class dopamine receptor D2 (DRD2) antagonist and mitochondrial protease ClpP agonist that is well tolerated and induces durable tumor regressions in H3 K27M-mutant glioma patients. ONC206, a chemical derivative of ONC201 currently in Phase I trials for central nervous system tumors, is also a DRD2 and ClpP dual targeting imipridone with differentiated target engagement and nanomolar potency. We explored molecular...