The impact of hypoxia on B cells in COVID-19
Abstract
Prominent early features of COVID-19 include severe, often clinically silent, hypoxia and a pronounced reduction in B cells, the latter important in defence against SARS-CoV-2. This brought to mind the phenotype of mice with VHL-deficient B cells, in which Hypoxia-Inducible Factors are constitutively active, suggesting hypoxia might drive B cell abnormalities in COVID-19. We demonstrated the breadth of early and persistent defects in B cell...
Paper Details
Title
The impact of hypoxia on B cells in COVID-19
Published Date
Jul 15, 2021
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