Mechanical load regulates bone growth via periosteal Osteocrin
Abstract
Mechanical stimuli including loading after birth promote bone growth. However, little is known about how mechanical force triggers biochemical signals to regulate bone growth. Here, we identified a periosteal-osteoblast-derived secretory peptide, Osteocrin (OSTN), as a mechanotransducer involved in load-induced long bone growth. OSTN produced by periosteal osteoblasts regulates growth plate growth by enhancing C-type natriuretic peptide...
Paper Details
Title
Mechanical load regulates bone growth via periosteal Osteocrin
Published Date
Jul 1, 2021
Journal
Volume
36
Issue
2
Pages
109380 - 109380
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