CD16+CD163+ monocytes traffic to sites of inflammation during necrotizing enterocolitis in premature infants
Abstract
Necrotizing enterocolitis (NEC) is a severe gastrointestinal complication of prematurity. Using suspension and imaging mass cytometry coupled with single-cell RNA sequencing, we demonstrate severe inflammation in patients with NEC. NEC mucosa could be subtyped by an influx of three distinct neutrophil phenotypes (immature, newly emigrated, and aged). Furthermore, CD16+CD163+ monocytes/Mϕ, correlated with newly emigrated neutrophils, were...
Paper Details
Title
CD16+CD163+ monocytes traffic to sites of inflammation during necrotizing enterocolitis in premature infants
Published Date
Jul 16, 2021
Volume
218
Issue
9
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