NMDAR in bladder smooth muscle is not a pharmacotherapy target for overactive bladder in mice

Overactive bladder (OAB) is a common condition that affects a significant patient population. The N-methyl-D-aspartate receptor (NMDAR) has a role in developing bladder overactivity, pharmacological inhibition of which inhibits bladder overactivity. The common pathogenesis of OAB involves bladder smooth muscle (BSM) overactivity. In this study, a smooth muscle–specific NMDAR knockout ( SMNRKO ) mouse model was generated. The bladders from SMNRKO...