Prognostic biomarkers to identify patients likely to develop severe Crohn’s disease: a systematic review

Identification of biomarkers that predict severe Crohn's disease is an urgent unmet research need, but existing research is piecemeal and haphazard.To identify biomarkers that are potentially able to predict the development of subsequent severe Crohn's disease.This was a prognostic systematic review with meta-analysis reserved for those potential predictors with sufficient existing research (defined as five or more primary studies).PubMed and...