Development of a Molecular Recognition Electrode and Investigation of a Biomolecular Application in Non-Aqueous Media —Electrochemical Detection of Uremia-Related Substances Excreted via ATP-Binding Cassette Transporter G2—

Detection methods for small biological molecules are needed to facilitate analysis of physiological and pathological mechanisms. We aimed to construct a 2-mercaptobenzimidazole modified gold nanoparticle electrode for detection of uremia-related substances, e.g. uric acid (UA) and indoxyl sulfate (IS), excreted via transporters expressed on cultured cells. This electrode detected the current changes in phosphate buffer at different potentials as...