A transcriptomic model for homologous recombination deficiency in prostate cancer

Volume: 25, Issue: 4, Pages: 659 - 665
Published: Jul 5, 2021
Abstract
Tumors with mutations associated with homologous recombination deficiency (HRD) are uncommon in prostate cancer (PCa) and variably responsive to PARP inhibition. To better identify tumors with HRD, we developed a transcriptomic signature for HRD in PCa (HRD-P). By using an established mutational signature, we created and validated HRD-P in six independent PCa cohorts (primary PCa, n = 8224; metastatic castration-resistant PCa [mCRPC], n = 328)....
Paper Details
Title
A transcriptomic model for homologous recombination deficiency in prostate cancer
Published Date
Jul 5, 2021
Volume
25
Issue
4
Pages
659 - 665
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