Serum CK-MB, COVID-19 severity and mortality: An updated systematic review and meta-analysis with meta-regression

We conducted a systematic review and meta-analysis with meta-regression of creatine kinase-MB (CK-MB), a biomarker of myocardial injury, in COVID-19 patients.We searched PubMed, Web of Science and Scopus, for studies published between January 2020 and January 2021 that reported CK-MB, COVID-19 severity and mortality (PROSPERO registration number: CRD42021239657).Fifty-five studies in 11,791 COVID-19 patients were included in the meta-analysis....