Necrostatin-1 reduces cardiac and mitochondrial dysfunction in prediabetic rats
Abstract
High-fat diet (HFD) consumption induces prediabetes and left ventricular dysfunction through many pathways including cell death pathway like necroptosis. Although the benefit of necroptosis inhibitor (necrostatin-1 or Nec-1) in the brain of prediabetic rats was shown, the effects of Nec-1 on cardiac autonomic function, blood pressure, cardiac function, along with its mechanistic insight have not been investigated. Male Wistar rats were fed with...
Paper Details
Title
Necrostatin-1 reduces cardiac and mitochondrial dysfunction in prediabetic rats
Published Date
Oct 1, 2021
Journal
Volume
251
Issue
1
Pages
27 - 39
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