Variation in dissolution behavior among different nanoforms and its implication for grouping approaches in inhalation toxicity
Abstract
Different nanoforms (NF) of the same substance each need to be registered under REACH, but similarities in physiological interaction -among them biodissolution- can justify read-across within a group of NFs, thereby reducing the need to perform animal studies. Here we focused on the endpoint of inhalation toxicity and explored how differences in physical parameters of 17 NFs of silica, and organic and inorganic pigments impact dissolution rates,...
Paper Details
Title
Variation in dissolution behavior among different nanoforms and its implication for grouping approaches in inhalation toxicity
Published Date
Jul 1, 2021
Journal
Volume
23
Pages
100341 - 100341
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