Carbonic anhydrase inhibitors suppress seizures in a rat model of birth asphyxia
Abstract
Seizures are common in neonates recovering from birth asphyxia but there is general consensus that current pharmacotherapy is suboptimal and that novel antiseizure drugs are needed. We recently showed in a rat model of birth asphyxia that seizures are triggered by the post-asphyxia recovery of brain pH. Here our aim was to investigate whether carbonic anhydrase inhibitors (CAIs), which induce systemic acidosis, block the post-asphyxia...
Paper Details
Title
Carbonic anhydrase inhibitors suppress seizures in a rat model of birth asphyxia
Published Date
Jun 27, 2021
Journal
Volume
62
Issue
8
Pages
1971 - 1984
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