Comment on "Vila-Córcoles et al., Clinical effectiveness of 13-valent and 23-valent pneumococcal vaccination in middle-aged and older adults: The EPIVAC cohort study, 2015-2016."

Published on Jul 1, 2021in Vaccine3.143
· DOI :10.1016/J.VACCINE.2020.11.036
Bradford D Gessner9
Estimated H-index: 9
Christian Theilacker3
Estimated H-index: 3
+ 1 AuthorsLuis Jodar11
Estimated H-index: 11
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Abstract Background We conducted a post-hoc analysis of a double blind, randomized, placebo-controlled trial of 13-valent pneumococcal conjugate vaccine (PCV13) among adults aged 65 years or older to assess public health impact. Methods For all outcomes, we included all randomized subjects, using a modified intention-to-treat (mITT) approach to determine vaccine efficacy (VE), vaccine preventable disease incidence (VPDI) defined as control minus vaccinated group incidence, and numbers needed to ...
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: In this population-based study evaluating the effectiveness of the 13-valent pneumococcal conjugate vaccine (2012-2016) to prevent all-cause pneumonia in adults ≥60 years of age, we found significant, 0.63% absolute risk and 11.9% relative risk reductions on the 3-year (2014-2016) cumulative incidences of all-cause pneumonia after vaccination.
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