Activation of α7 nicotinic acetylcholine receptor ameliorates HIV-associated neurology and neuropathology
Abstract
HIV-associated neurocognitive disorders (HAND) in the era of combination antiretroviral therapy are primarily manifested as impaired behaviours, glial activation/neuroinflammation and compromised neuronal integrity, for which there are no effective treatments currently available. In the current study, we used doxycycline-inducible astrocyte-specific HIV Tat transgenic mice (iTat), a surrogate HAND model, and determined effects of PNU-125096, a...
Paper Details
Title
Activation of α7 nicotinic acetylcholine receptor ameliorates HIV-associated neurology and neuropathology
Published Date
Jul 1, 2021
Journal
Volume
144
Issue
11
Pages
3355 - 3370
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