A PDZ Protein GIPC3 Positively Modulates Hedgehog Signaling and Melanoma Growth
Volume: 142, Issue: 1, Pages: 179 - 188.e4
Published: Jan 1, 2022
Abstract
The hedgehog (Hh) pathway is essential for animal development, but aberrant activation promotes cancer growth. In this study, we show that GIPC3, a PDZ domain-containing protein with putative adaptor protein function, positively modulates Hh target gene expression in normal fibroblasts and melanoma cells and supports melanoma tumor growth. Using overexpression and epistasis studies, we show that Gipc3 potentiates Hh transcriptional output and...
Paper Details
Title
A PDZ Protein GIPC3 Positively Modulates Hedgehog Signaling and Melanoma Growth
Published Date
Jan 1, 2022
Volume
142
Issue
1
Pages
179 - 188.e4
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