Inhibition of PI3K/mTOR/KATP channel blunts sodium thiosulphate preconditioning mediated cardioprotection against ischemia–reperfusion injury

Volume: 44, Issue: 6, Pages: 605 - 620
Published: Jun 1, 2021
Abstract
Recent studies have shown that pre and postconditioning the heart with sodium thiosulfate (STS) attenuate ischemia–reperfusion (IR) injury. However, the underlying mechanism involved in the cardioprotective signaling pathway is not fully explored. This study examined the existing link of STS mediated protection (as pre and post-conditioning agents) with PI3K, mTOR, and mPTP signaling pathways using its respective inhibitors. STS was administered...
Paper Details
Title
Inhibition of PI3K/mTOR/KATP channel blunts sodium thiosulphate preconditioning mediated cardioprotection against ischemia–reperfusion injury
Published Date
Jun 1, 2021
Volume
44
Issue
6
Pages
605 - 620
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