Effect of Perioperative Intravenous iron Supplementation for Complex Cardiac Surgery on Transfusion Requirements: A Randomized, Double-Blinded Placebo-Controlled Trial.

OBJECTIVES We investigated whether routine perioperative intravenous iron replenishment reduces the requirement for packed erythrocytes (pRBC) transfusion. SUMMARY BACKGROUND DATA Patients undergoing complex cardiac surgery are at high risk of developing postoperative iron deficiency anemia, thus requiring transfusion, which is associated with adverse outcomes. METHODS Patients were randomized to receive either ferric derisomaltose 20 mg/kg (n =...