Tribbles homolog 3-mediated targeting the AKT/mTOR axis in mice with retinal degeneration
Volume: 12, Issue: 7
Published: Jul 2, 2021
Abstract
Various retinal degenerative disorders manifest in alterations of the AKT/mTOR axis. Despite this, consensus on the therapeutic targeting of mTOR in degenerating retinas has not yet been achieved. Therefore, we investigated the role of AKT/mTOR signaling in rd16 retinas, in which we restored the AKT/mTOR axis by genetic ablation of pseudokinase TRB3, known to inhibit phosphorylation of AKT and mTOR. First, we found that TRB3 ablation resulted in...
Paper Details
Title
Tribbles homolog 3-mediated targeting the AKT/mTOR axis in mice with retinal degeneration
Published Date
Jul 2, 2021
Volume
12
Issue
7
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