CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases
Abstract
Mutations in Valosin Containing Protein (VCP) are associated with several degenerative diseases, including multisystem proteinopathy (MSP-1) and amyotrophic lateral sclerosis. However, patients with VCP mutations vary widely in their pathology and clinical penetrance, making it difficult to devise effective treatment strategies. A deeper understanding of how each mutation affects VCP function could enhance the prediction of clinical outcomes and...
Paper Details
Title
CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases
Published Date
Jul 1, 2021
Journal
Volume
14
Issue
7
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