Endothelial dysfunction and its critical role in COVID‐19‐associated coagulopathy: Defibrotide as an endothelium‐protective, targeted therapy

To the Editor: Recent publications emphasize that patients with COVID-19 commonly present with lethal disseminated intravascular coagulopathy (DIC) characterized by increased levels of D-dimer, fibrinogen, and elevated prothrombin time and activated partial thromboplastin time [1]. These abnormalities are associated with increased rates of thromboembolism and a profound prothrombotic state. However, other authors have found that both severe and...