Sleep Disturbance is Associated With Higher Plasma Aβ Levels in Cognitively Normal Adults—A Population-Based Cross-Sectional Study

Objective: Growing evidence suggests that sleep disturbance is a risk factor for Alzheimer's disease (AD). Amyloid-β (Aβ) deposition in the brain is a main pathophysiology of AD. Considering that peripheral Aβ level is associated with brain Aβ deposition, the present study investigated the relationship between sleep disturbance and plasma Aβ levels. Methods: This is a population-based cross-sectional study. A total of 1,459 participants from a...