SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
Abstract
Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune responses as observed in severe and long COVID-19 patients. Here we show that SARS-CoV-2 modulates cellular metabolism and reduces autophagy. Accordingly, compound-driven induction of autophagy limits SARS-CoV-2 propagation. In detail, SARS-CoV-2-infected cells show accumulation...
Paper Details
Title
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
Published Date
Jun 21, 2021
Journal
Volume
12
Issue
1
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