Pharmacokinetics and tolerance of repeated oral administration of 5-fluorocytosine in healthy dogs
Abstract
5-fluorocytosine is a pyrimidine and a fluorinated cytosine analog mainly used as an antifungal agent. It is a precursor of 5-fluorouracil, which possesses anticancer properties. To reduce systemic toxicity of 5-fluorouracil during chemotherapy, 5- fluorocytosine can be used as a targeted anticancer agent. Expression of cytosine deaminase by a viral vector within a tumor allows targeted chemotherapy by converting 5-fluorocytosine into the...
Paper Details
Title
Pharmacokinetics and tolerance of repeated oral administration of 5-fluorocytosine in healthy dogs
Published Date
Jun 21, 2021
Journal
Volume
17
Issue
1
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