Fabrication of gelatin methacryloyl hydrogel microneedles for transdermal delivery of metformin in diabetic rats

Injection therapy for diabetes has poor patient compliance, and the pain occurring at the site of subcutaneous injections causes significant inconvenience to diabetic patients. In this work, to demonstrate the benefits of an alternative drug delivery technique that overcomes these issues, methacrylated gelatin hydrogel-forming microneedles integrated with metformin were developed to adjust blood glucose levels in diabetic rats. Gelatin...