Culprit site extracellular DNA and microvascular obstruction in ST-elevation myocardial infarction
Abstract
Extracellular chromatin and deoxyribonuclease (DNase) have been identified as important players of thrombosis, inflammation, and homeostasis in a murine model. We previously demonstrated that activated neutrophils release neutrophil extracellular traps (NETs) at the culprit site in ST-elevation myocardial infarction (STEMI), which significantly contribute to extracellular chromatin burden, and are associated with larger infarcts. To understand...
Paper Details
Title
Culprit site extracellular DNA and microvascular obstruction in ST-elevation myocardial infarction
Published Date
Jun 26, 2021
Journal
Volume
118
Issue
8
Pages
2006 - 2017
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