Nitrene transfer catalysts for enantioselective C–N bond formation

Transition-metal-catalysed, non-enzymatic transformations of C–H and C=C bonds to C–N bonds through nitrene transfer (NT) are powerful synthetic tools to prepare valuable amine building blocks. Although the first examples of racemic NT were reported more than 50 years ago, catalysts that mediate enantioselective NT with a broad substrate scope have been slow to emerge. However, the past ten years have seen the discovery of several first-row,...