Diet-regulated production of PDGFcc by macrophages controls energy storage
Abstract
The mechanisms by which macrophages regulate energy storage remain poorly understood. We identify in a genetic screen a platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF)-family ortholog, Pvf3, that is produced by macrophages and is required for lipid storage in fat-body cells of Drosophila larvae. Genetic and pharmacological experiments indicate that the mouse Pvf3 ortholog PDGFcc, produced by adipose...
Paper Details
Title
Diet-regulated production of PDGFcc by macrophages controls energy storage
Published Date
Jul 2, 2021
Journal
Volume
373
Issue
6550
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