Kinase

Function (biology)

Cell biology

Metastasis

Biology

Proto-oncogene tyrosine-protein kinase Src

Signal transducing adaptor protein

Phosphorylation

SH3 domain

Genetics

Epithelial–mesenchymal transition

Actin

Actin cytoskeleton

Cytoskeleton

Cell

Cancer

Cell Communication and Signaling

Over a century of scientific inquiry since the discovery of v-SRC but still no final judgement on SRC function. However, a significant body of work has defined Src family kinases as key players in tumor progression, invasion and metastasis in human cancer. With the ever-growing evidence supporting the role of epithelial-mesenchymal transition (EMT) in invasion and metastasis, so does our understanding of the role SFKs play in mediating these processes. Here we describe some key mechanisms through which Src family kinases play critical role in epithelial homeostasis and how their function is essential for the propagation of invasive signals. Video abstract.

Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition