A GH89 human α-N-acetylglucosaminidase (hNAGLU) homologue from gut microbe Bacteroides thetaiotaomicron capable of hydrolyzing heparosan oligosaccharides

Volume: 11, Issue: 1
Published: Jun 24, 2021
Abstract
Carbohydrate-Active enZYme (CAZY) GH89 family enzymes catalyze the cleavage of terminal α- N -acetylglucosamine from glycans and glycoconjugates. Although structurally and mechanistically similar to the human lysosomal α- N -acetylglucosaminidase (hNAGLU) in GH89 which is involved in the degradation of heparan sulfate in the lysosome, the reported bacterial GH89 enzymes characterized so far have no or low activity toward α- N...
Paper Details
Title
A GH89 human α-N-acetylglucosaminidase (hNAGLU) homologue from gut microbe Bacteroides thetaiotaomicron capable of hydrolyzing heparosan oligosaccharides
Published Date
Jun 24, 2021
Volume
11
Issue
1
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