Acute Inhibition of Connexin43 Expression Promotes Vesicant Wound Repair in a Nitrogen Mustard Induced Hairless Mouse Cutaneous Injury Model

The gap‐junction proteins, the connexins, mediate intercellular communication and play a significant regulatory role in wound repairs. Recent studies showed that transient inhibition of connexin43 (Cx43) expression resulted in accelerated wound healing in both incisional and burn skin wounds. Skin wounds caused by vesicants generally result in an acute immune response and delayed wound repairs. We tested Cx43 antisense oligodeoxynucleotides...