Glycosylated Nanotherapeutics with β-Lactamase Reversible Competitive Inhibitory Activity Reinvigorates Antibiotics against Gram-Negative Bacteria.
Abstract
Antibiotics are currently first-line therapy for bacterial infections. However, the curative effect of antibiotic remedies is limited due to increasingly prevalent bacterial resistance. The strategy to reverse intrinsic acquired drug resistance presents a promising option for reinvigorating antibiotic therapy. Here, we developed a β-lactamase-inhibiting macromolecule composed of benzoxaborole and dextran for precise transport of β-lactam...
Paper Details
Title
Glycosylated Nanotherapeutics with β-Lactamase Reversible Competitive Inhibitory Activity Reinvigorates Antibiotics against Gram-Negative Bacteria.
Published Date
Jun 24, 2021
Journal
Volume
22
Issue
7
Pages
2834 - 2849
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Notes
History