STAT3/HIF-1α signaling activation mediates peritoneal fibrosis induced by high glucose

Volume: 19, Issue: 1
Published: Jun 30, 2021
Abstract
Background Epithelial-mesenchymal transition (EMT) of mesothelial cells is a key step in the peritoneal fibrosis (PF). Recent evidence indicates that signal transducer and activator of transcription 3 (STAT3) might mediate the process of renal fibrosis, which could induce the expression of hypoxia-inducible factor-1α (HIF-1α). Here, we investigated the effect of STAT3 activation on HIF-1α expression and the EMT of mesothelial cells, furthermore...
Paper Details
Title
STAT3/HIF-1α signaling activation mediates peritoneal fibrosis induced by high glucose
Published Date
Jun 30, 2021
Volume
19
Issue
1
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