Microbial short-chain fatty acids modulate CD8 + T cell responses and improve adoptive immunotherapy for cancer

Volume: 12, Issue: 1, Pages: 4077 - 4077
Published: Jul 1, 2021
Abstract
Emerging data demonstrate that the activity of immune cells can be modulated by microbial molecules. Here, we show that the short-chain fatty acids (SCFAs) pentanoate and butyrate enhance the anti-tumor activity of cytotoxic T lymphocytes (CTLs) and chimeric antigen receptor (CAR) T cells through metabolic and epigenetic reprograming. We show that in vitro treatment of CTLs and CAR T cells with pentanoate and butyrate increases the function of...
Paper Details
Title
Microbial short-chain fatty acids modulate CD8 + T cell responses and improve adoptive immunotherapy for cancer
Published Date
Jul 1, 2021
Volume
12
Issue
1
Pages
4077 - 4077
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